4CMC, also known as Clephedrone, is a stimulant drug of the cathinone class that has been sold online as a designer drug.
In radioligand binding assays, 4-CMC had very low affinities of 9,410 nM, 28,700 nM, and 19,600 nM for the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET), respectively. In uptake potency assays, 4-CMC had low uptake potencies of 208 nM, 670 nM, and 75.5nM for the DAT, SERT, and NET, respectively. 4-CMC possessed full efficacy at stimulating the release of dopamine. The maximal response elicited by 4-CMC was 83.5% of the efficacy of methamphetamine. The maximal response elicited by 4-CMC was 124% of the maximal efficacy of methamphetamine. 4-CMC was more potent (EC50value = 1,980 nM) at stimulating release of serotonin compared to methamphetamine (27,500 nM).